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JUNE 16, 2017

The DrugAge database of aging-related drugs

Barardo D(1), Thornton D(1), Thoppil H(1,2), Walsh M(3), Sharifi S(1), Ferreira S(1), Anžič A(1), Fernandes M(1), Monteiro P(1), Grum T(1), Cordeiro R(1), De-Souza EA(4), Budovsky A(5,6), Araujo N(1), Gruber J(7,8), Petrascheck M(9), Fraifeld VE(5), Zhavoronkov A(10,11), Moskalev A(12,13,14), de Magalhães JP(1,11).

(1) Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

(2) Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham (Amrita University), Coimbatore, India.

(3) Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.

(4) Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil.

(5) The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva, Israel.

(6) Judea Regional Research & Development Center, Carmel, 90404, Israel.

(7) Department of Science, Yale- NUS College, Singapore City, 138527, Singapore.

(8) Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, 117597, Singapore.

(9) Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.

(10) Pharmaceutical Artificial Intelligence Research Division, Emerging Technology Centers, Insilico Medicine, Inc, Johns Hopkins University at Eastern, B301, 1101 33rd Street, Baltimore, MD, 21218, USA.

(11) The Biogerontology Research Foundation, Oxford, UK.

(12) Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia.

(13) Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia.

(14) Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, 119991, Russia.

Abstract

Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.

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